FOUNDER'S THOUGHTS -

Publish in the Journal of carcinogenesis

Despite the advances in the treatment of cancer and the increasing knowledge of the processes responsible for the disease, there is a gap in the understanding of molecular events leading to cancer and the mechanisms of action by anticancer agents

The field of carcinogenesis is far from being completely explored. Many novel ideas and concepts still need to be introduced into the field, and the results of several provocative experiments are yet to be disseminated and shared. There is a need for multidisciplinary research in the field and a forum for accelerated publication of results.

Carcinogenesis Foundation is primed to race against Cancer

Cancer-free world is possible through Research, Awareness, Care and Education -RACE. I want to invite you to join Carcinogenesis Foundation which is an organization consisting of scientists, doctors, educators, social workers and concerned citizens like you who care for our communities. Carcinogenesis Foundation strives to understand the cancer causing processes. Do you know most cancers are not hereditary but acquired and therefore preventable? Obviously, we need to know what causes cancer in humans in order to be able to prevent it. Several factors like diet, environment and genetic background play a key role in developing cancers.

Intriguingly, susceptibility to cancer varies among various populations. For example, African Americans who smoke are likely to be at a higher risk for developing lung cancer compared to other ethnic groups. It is also interesting that migration to western countries increases risk for n cancer incidence, which can be conceptualized as Acquired Risk for Cancer Incidence (ARCI). This phenomenon suggests a specific role for gene-environment interactions in carcinogenesis process. Therefore, I believe that we can tap on the diversity of human genome to find clues and answers for the origin of cancers. The mission of Carcinogenesis Foundation is-Prevention, Innovation, Medicine and Education-PRIME.

What is the need for Carcinogenesis Foundation?

In the past few years cancer has become a disease of greater concern and fear among the public as it places a significant emotional and economic burden on the families and governments. While discoveries in the field of cancer treatment interest the cancer patients, information and insights into the cause of cancers and possibilities for its prevention interests society at-large. Increasing exposure to the advances in research and treatment of cancers through the media has led to increased anticipation and expectations among the public. Educated public are looking for credible suggestions on healthy dietary and lifestyle choices.

Unfortunately, conflicting reports on cancer causing potential and cancer prevention efficacy of various diets and dietary supplements leave the public confused and reticent about the results of scientific research. There are several reasons for the lack of clear answers to questions related to carcinogenesis and cancer prevention; absence of clear and defined models and markers of carcinogenesis is one of the major reasons. Lack of consensus among scientists on these issues adds to the difficulties in the field of carcinogenesis research.

Until recently, design of anticancer drugs focused on the ability of compounds to kill the cells irrespective of the origin and source of abnormality or the pathways that led to the birth of abnormal cells. A clear knowledge and understanding of the molecular processes that underlie the transformation of normal cells to cancer cells will lead to effective prevention and treatment of cancers in humans. This objective can be achieved through the collective efforts led by an organization that is committed to understand the genesis of cancers and applying the knowledge for cancer prevention. An organization that can bring together the ideas, resources, expertise and technologies to make a difference in the lives of people around the world will be the key to achieving a cancer-free world. Carcinogenesis Foundation was founded to fulfill this objective and citizens of the world will be its stakeholders.

You can play a role in cancer research through Carcinogenesis Foundation in more than one way. You may choose to volunteer in various ways or make a financial contribution to the foundation. You may just choose to say `thank you’ to those who discover, care, cure and educate. Any of these actions by you will have a positive impact on understanding the cancer causing processes and thereby on global cancer prevention efforts. Please support RACE activities of Carcinogenesis Foundation

I would love to hear from you.

Sincerely,

Gopala Kovvali Ph.D.
Founder and President,
Carcinogenesis Foundation
Gopala@carcinogenesis.com

WHO Recommendations for Cancer Prevention

Maintain weight (among adults) such that BMI is in the range of 18.5-24.9 kg/m2 and avoid weight gain (>5 kg) during adult life.
Maintain regular physical activity. The primary goal should be to perform physical activity on most days of the week; 60 minutes per day of moderate-intensity activity, such as walking, may be needed to maintain healthy body weight in otherwise sedentary people. More vigorous activity, such as fast walking, may give some additional benefits for cancer prevention.
Consumption of alcoholic beverages is not recommended: if consumed, do not exceed two units per day.
Chinese-style fermented salted fish should only be consumed in moderation, especially during childhood. Overall consumption of salt-preserved foods and salt should be moderate.
Minimize exposure to aflatoxin in foods.
Have a diet which includes at least 400 g per day of total fruits and vegetables.
Those who are not vegetarian are advised to moderate consumption of preserved meat (e.g. sausages, salami, bacon, ham).
Do not consume foods or drinks when they are at a very hot (scalding hot) temperature.

Lifestyle and Cancer incidence (Source: National Cancer Institute, USA)

30-35% of cancers are related to dietary factors

Sedentarism is an important cause of cancer

30% of cancers are related to smoking
Obesity is related to 14-20% of cancers in the US

Alcohol is resposible for about 3% of cancer deaths

Environmental factors, such as pollution and radiation, are contributors to cancer

En estimated 90% of colorectal cancers could be prevented by colonoscopy and other early detection testes

Early detection can decrease mortality by cervical, prostate and breast cancer.